I remember from the old TechTV days a project by Patrick Norton. He was building an ultimate computer for that time. The project was to use best motherboard, video card, etc. The processor was an AMD Athlon (don't remember the clock speed). All of the fabrication was accomplished live over a period of days.

The thing that makes this story relevant to this topic is that Patrick succeeded in frying two different CPUs. There was visible smoke with one.