Thanks everyone for your replies and suggestions. This is what I have done so far. I went in and did that RESTORE DEFAULTS per Reverend. I then did a disk cleanup. I have Adaware 6 on my computer so I ran it again. It found 21 files that I then deleted. I then ran Perfect Disk 6.0 and defragged my system. The last three times I opened IE, I had no problem. It opened like it should. By the way, I do not have any other Browser on my computer, only IE. I will post back again if the problem reappears. Hopefully it is corrected. Many thanks to Reverend, efc, and egghead.